TY - JOUR
KW - Adult
KW - Bangladesh
KW - BCG Vaccine
KW - Chemoprevention
KW - Double-Blind Method
KW - Female
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Male
KW - Rifampin
KW - Young Adult
AU - Schuring RP
AU - Richardus JH
AU - Pahan D
AU - Oskam L
AB - <p>BCG vaccination and rifampicin chemoprophylaxis are both strategies for leprosy prevention. While the combined effect is unknown, the combination may give the desired push to halt leprosy transmission. Secondary analysis was done on results from a single centre, double blind, cluster randomized, and placebo-controlled trial. Individually, BCG (given at infancy) and rifampicin showed to protect against leprosy (57% [95% CI: 24-75%] and 58% [95% CI: 30-74%], respectively). The combined strategies showed a protective effect of 80% (95% CI: 50-92%). This is the first time that the additive effect of BCG and rifampicin are shown; the combined strategies can possibly lower leprosy incidence.</p>
BT - Vaccine
C1 - http://www.ncbi.nlm.nih.gov/pubmed/19786134?dopt=Abstract
DA - 2009 Nov 23
DO - 10.1016/j.vaccine.2009.09.054
IS - 50
J2 - Vaccine
LA - eng
N2 - <p>BCG vaccination and rifampicin chemoprophylaxis are both strategies for leprosy prevention. While the combined effect is unknown, the combination may give the desired push to halt leprosy transmission. Secondary analysis was done on results from a single centre, double blind, cluster randomized, and placebo-controlled trial. Individually, BCG (given at infancy) and rifampicin showed to protect against leprosy (57% [95% CI: 24-75%] and 58% [95% CI: 30-74%], respectively). The combined strategies showed a protective effect of 80% (95% CI: 50-92%). This is the first time that the additive effect of BCG and rifampicin are shown; the combined strategies can possibly lower leprosy incidence.</p>
PY - 2009
SP - 7125
EP - 8
T2 - Vaccine
TI - Protective effect of the combination BCG vaccination and rifampicin prophylaxis in leprosy prevention.
VL - 27
SN - 1873-2518
ER -