TY - JOUR KW - T regulatory cells KW - immunosuppression KW - leprosy KW - leprosy reaction AU - Cardona C AU - Vieira A AU - Avancini J AU - Duarte A AU - Trindade M AU - Benard G AB -

Knowledge of the role of Tregs in the immunopathogenesis of the different clinical outcomes within the leprosy spectrum remains limited due to the lack of studies directly assessing their suppression capacity. We thus tested a protocol to expand Tregs from the peripheral blood of patients across the leprosy spectrum and analyzed their suppressive capacity in autologous TCD4+ responses. Results of these pilot assays show that Tregs can be expanded and exert suppressive capacity, but also that their rate of expansion and suppressive capacity are influenced by the patient's clinical classification, suggesting that they possibly retain some in vivo characteristics.

BT - Microbes and infection C1 - https://www.ncbi.nlm.nih.gov/pubmed/31857221 DA - 12/2019 DO - 10.1016/j.micinf.2019.12.002 J2 - Microbes Infect. LA - eng N2 -

Knowledge of the role of Tregs in the immunopathogenesis of the different clinical outcomes within the leprosy spectrum remains limited due to the lack of studies directly assessing their suppression capacity. We thus tested a protocol to expand Tregs from the peripheral blood of patients across the leprosy spectrum and analyzed their suppressive capacity in autologous TCD4+ responses. Results of these pilot assays show that Tregs can be expanded and exert suppressive capacity, but also that their rate of expansion and suppressive capacity are influenced by the patient's clinical classification, suggesting that they possibly retain some in vivo characteristics.

PY - 2019 T2 - Microbes and infection TI - Expansion and suppressive capacity of regulatory T cells isolated from patients across the leprosy spectrum: a pilot study. SN - 1769-714X ER -