The ongoing transmission of leprosy in India is worrisome, and emerging drug resistance may be one of the factors responsible for the continued transmission of leprosy in India. Emerging cases of multidrug-resistant pose a great threat to eradication of leprosy and must be addressed with utmost priority. We report a case of multidrug-resistant in a case of relapse where slit skin smear (SSS) was negative and histopathology was inconclusive. Drug resistance studies in leprosy are undertaken only in smear-positive relapse cases, and detection of this type of multidrug resistance in a case with negative SSS and innocuous histopathology is rather unusual and highlights the importance of undertaking drug resistance tests even in smear-negative cases of leprosy relapse. Resistance to ofloxacin (OFL) is also a cause for concern as OFL is one of the reserve drugs recommended for treatment of rifampicin-resistant strains.
BT - The American journal of tropical medicine and hygiene C1 - https://www.ncbi.nlm.nih.gov/pubmed/32043454 DA - 02/2020 DO - 10.4269/ajtmh.19-0905 J2 - Am. J. Trop. Med. Hyg. LA - eng N2 -The ongoing transmission of leprosy in India is worrisome, and emerging drug resistance may be one of the factors responsible for the continued transmission of leprosy in India. Emerging cases of multidrug-resistant pose a great threat to eradication of leprosy and must be addressed with utmost priority. We report a case of multidrug-resistant in a case of relapse where slit skin smear (SSS) was negative and histopathology was inconclusive. Drug resistance studies in leprosy are undertaken only in smear-positive relapse cases, and detection of this type of multidrug resistance in a case with negative SSS and innocuous histopathology is rather unusual and highlights the importance of undertaking drug resistance tests even in smear-negative cases of leprosy relapse. Resistance to ofloxacin (OFL) is also a cause for concern as OFL is one of the reserve drugs recommended for treatment of rifampicin-resistant strains.
PY - 2020 T2 - The American journal of tropical medicine and hygiene TI - Case Report: Multidrug-Resistant Mycobacterium leprae in a Case of Smear-Negative Relapse. SN - 1476-1645 ER -