TY - JOUR
KW - Mycobacterium leprae
KW - leprosy
KW - mice
KW - real time PCR
AU - Karamova A
AU - Semenova V
AU - Verbenko D
AU - Obraztsova O
AU - Vanchugova K
AU - Nikonorov A
AU - Deryabin D
AU - Solomka V
AU - Kubanov A
AB - <p>Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6ТNF mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed a temporal-quantitative dependence on the used mouse line. CBA and BALB/cNude mice were optimal for strain R and BALB/c and BALB/cNude lines were optimal for strain I. BALB/cNude mice infected with strain I had low lifespan. M. leprae strain M showed low proliferation activity in BALB/cNude and C57BL/6ТNF mice.</p>
BT - Bulletin of experimental biology and medicine
C1 - https://www.ncbi.nlm.nih.gov/pubmed/33098510
DA - 10/2020
DO - 10.1007/s10517-020-04991-7
J2 - Bull Exp Biol Med
LA - eng
N2 - <p>Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6ТNF mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed a temporal-quantitative dependence on the used mouse line. CBA and BALB/cNude mice were optimal for strain R and BALB/c and BALB/cNude lines were optimal for strain I. BALB/cNude mice infected with strain I had low lifespan. M. leprae strain M showed low proliferation activity in BALB/cNude and C57BL/6ТNF mice.</p>
PY - 2020
T2 - Bulletin of experimental biology and medicine
TI - Experimental Modeling of Leprosy in BALB/c, BALB/c Nude, CBA, and C57BL/6ТNF Mice.
SN - 1573-8221
ER -