TY - JOUR
AU - Dubey A
AU - Gaur R
AU - Arela N
AU - Singh V
AU - Arora M
AU - Sagar H
AU - Kamal R
AU - Natarajan M
AU - Bhagyawant SS
AU - Patil SA
AU - Mohanty KK
AB - Background:<br>
The disease leprosy is categorized by a wide spectrum of clinical forms imposed by the patient’s immune responses to the organism, Mycobacterium leprae. Soluble receptors and soluble mediators are important for regulation of immune responses.
<br><br>
Objectives:<br>
As leprosy reactions are known immune inflammatory reactions during the disease process, the aim of the study was to screen nitrite, IL-6 cytokine and sTLR2 in sera samples to identify circulating biomarkers associated with leprosy and T1R and T2R among patients recruited from the Northern part of India.
<br><br>
Methods:<br>
Leprosy patients recruited in our Institute were included in this study. We analysed the level of nitrite, soluble TLR2 and IL-6 in sera of leprosy patients, healthy controls and healthy household contacts by colorimetric assay and ELISA respectively.
<br><br>
Results:<br>
The level of serum nitrite was observed to be higher in tuberculoid leprosy patients compared to lepromatous leprosy patients (p = 0.006). The level was also higher in healthy contacts of leprosy patients compared to lepromatous leprosy patients (p = 0.008). The sTLR2 level was significantly higher in healthy controls than leprosy patients (p = 0.002) and their healthy contacts (p = 0.001). The level of IL-6 in serum was significantly higher in leprosy patients than in healthy controls (p = 0.001).
<br><br>
Conclusion:<br>
Nitrite, IL-6 cytokine and sTLR2 are shown to be potential circulating biomarkers associated with leprosy among patients recruited in Northern India.
BT - Leprosy Review
DO - 10.47276/lr.91.4.403
IS - 4
LA - eng
N2 - Background:<br>
The disease leprosy is categorized by a wide spectrum of clinical forms imposed by the patient’s immune responses to the organism, Mycobacterium leprae. Soluble receptors and soluble mediators are important for regulation of immune responses.
<br><br>
Objectives:<br>
As leprosy reactions are known immune inflammatory reactions during the disease process, the aim of the study was to screen nitrite, IL-6 cytokine and sTLR2 in sera samples to identify circulating biomarkers associated with leprosy and T1R and T2R among patients recruited from the Northern part of India.
<br><br>
Methods:<br>
Leprosy patients recruited in our Institute were included in this study. We analysed the level of nitrite, soluble TLR2 and IL-6 in sera of leprosy patients, healthy controls and healthy household contacts by colorimetric assay and ELISA respectively.
<br><br>
Results:<br>
The level of serum nitrite was observed to be higher in tuberculoid leprosy patients compared to lepromatous leprosy patients (p = 0.006). The level was also higher in healthy contacts of leprosy patients compared to lepromatous leprosy patients (p = 0.008). The sTLR2 level was significantly higher in healthy controls than leprosy patients (p = 0.002) and their healthy contacts (p = 0.001). The level of IL-6 in serum was significantly higher in leprosy patients than in healthy controls (p = 0.001).
<br><br>
Conclusion:<br>
Nitrite, IL-6 cytokine and sTLR2 are shown to be potential circulating biomarkers associated with leprosy among patients recruited in Northern India.
PB - Lepra
PY - 2020
SP - 403
EP - 412
T2 - Leprosy Review
TI - Soluble mediators of immune significance in sera of leprosy patients
UR - https://leprosyreview.org/admin/public/article_shell/uploads/article_files/Lepra/LEPROSY/91/4/lr2020021/lr2020021.pdf
VL - 91
SN - 2162-8807
ER -