Background: Leprosy (Hansen's disease) is a chronic, debilitating disease predominantly of the peripheral nervous system characterized by the impairment of peripheral nerves and subsequent sensory loss caused by . The pro- and antiinflammatory cytokine genes play a major role in nerve damage in leprosy.
Aims and Objectives: The objective of the present study is to ascertain the association of cytokine gene polymorphisms TNFα - 308G/A (rs 1800629), IFNγ +874A/T (rs 2430561), and IL10 - 1082G/A rs 1800896 in causation with leprosy.
Materials and Methods: The present study comprised 365 leprosy patients and 185 control subjects. The polymorphisms in TNFα-308, IFNγ+874, and IL10-1082 genes were typed using the amplification refractory mutation system polymerase chain reaction method (ARMS PCR).
Results: The present study found significant association between IL10-1082 GA heterozygote ( < 0.02) and IFNγ+874 AA ( < 0.001) genotype and leprosy. TNFα-308GA could not establish any association with the disease.
Conclusion: The identification of genetic variations in pro- and antiinflammatory cytokines that are susceptible to leprosy would assist in better understanding of the pathogenesis of leprosy and perhaps lead to new approaches for diagnosis and treatment.
BT - Indian journal of dermatology C1 - https://www.ncbi.nlm.nih.gov/pubmed/34188268 DA - 01/2021 DO - 10.4103/ijd.IJD_684_20 IS - 2 J2 - Indian J Dermatol LA - eng N2 -Background: Leprosy (Hansen's disease) is a chronic, debilitating disease predominantly of the peripheral nervous system characterized by the impairment of peripheral nerves and subsequent sensory loss caused by . The pro- and antiinflammatory cytokine genes play a major role in nerve damage in leprosy.
Aims and Objectives: The objective of the present study is to ascertain the association of cytokine gene polymorphisms TNFα - 308G/A (rs 1800629), IFNγ +874A/T (rs 2430561), and IL10 - 1082G/A rs 1800896 in causation with leprosy.
Materials and Methods: The present study comprised 365 leprosy patients and 185 control subjects. The polymorphisms in TNFα-308, IFNγ+874, and IL10-1082 genes were typed using the amplification refractory mutation system polymerase chain reaction method (ARMS PCR).
Results: The present study found significant association between IL10-1082 GA heterozygote ( < 0.02) and IFNγ+874 AA ( < 0.001) genotype and leprosy. TNFα-308GA could not establish any association with the disease.
Conclusion: The identification of genetic variations in pro- and antiinflammatory cytokines that are susceptible to leprosy would assist in better understanding of the pathogenesis of leprosy and perhaps lead to new approaches for diagnosis and treatment.
PY - 2021 SP - 138 EP - 144 T2 - Indian journal of dermatology TI - A Study on the Impact of Genetic Polymorphisms of Cytokines TNFα, IFNγ and IL10 in South Indian Leprosy Patients. UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208288/ VL - 66 SN - 1998-3611 ER -