Primary hyperpigmentation is rare in leprosy. We report a patient with borderline lepromatous (BL) leprosy who presented with both hypopigmented and hyperpigmented macules. Histopathology with Masson Fontana staining and immunohistochemistry with HMB 45 revealed decreased melanin granules in keratinocytes of basal and superficial layers in hypopigmented macules when compared to hyperpigmented macules. It appears that hypopigmentation in leprosy lesions may be due to defective transfer of melanin into keratinocytes.
BT - Leprosy Review DO - 10.47276/lr.92.4.412 IS - 4 LA - eng N2 -Primary hyperpigmentation is rare in leprosy. We report a patient with borderline lepromatous (BL) leprosy who presented with both hypopigmented and hyperpigmented macules. Histopathology with Masson Fontana staining and immunohistochemistry with HMB 45 revealed decreased melanin granules in keratinocytes of basal and superficial layers in hypopigmented macules when compared to hyperpigmented macules. It appears that hypopigmentation in leprosy lesions may be due to defective transfer of melanin into keratinocytes.
PB - Lepra PY - 2021 SP - 412 EP - 420 T2 - Leprosy Review TI - A unique case of borderline lepromatous leprosy presenting with both hypopigmented and hyperpigmented macules UR - https://leprosyreview.org/admin/public/api/lepra/website/getDownload/61b84885afaac1246d764255 VL - 92 SN - 2162-8807 ER -