TY - JOUR
KW - Antigen-Presenting Cells
KW - Endothelium
KW - Fibroblasts
KW - Histocompatibility Antigens Class II
KW - Humans
KW - Immunohistochemistry
KW - leprosy
KW - Lymphocytes
KW - Macrophages
KW - Microscopy, Electron
KW - Peripheral nerves
AU - Cowley S A
AU - Gschmeissner S E
AU - Negesse Y
AU - Curtis J
AU - Turk J L
AB - <p>A technique for immunoelectronmicroscopy has been used to investigate major histocompatibility class II expression in leprosy nerves. In normal nerves, endothelial cells and occasional endoneural cells (not Schwann cells) were constitutively class II positive. In both paucibacillary and multibacillary leprosy nerve biopsies, infiltrating leukocytes were positive but class II-positive Schwann cells were not seen. These observations indicate that Schwann cells may not be involved in presenting Mycobacterium leprae antigens to T cells in leprosy. This conflicts with evidence from in vitro studies, but may be explained by the fact that in vivo Schwann cells are surrounded by basement membranes and are closely associated with axons.</p>
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/2401839?dopt=Abstract
CN - COWLEY1990
DA - 1990 Sep
IS - 3
J2 - Int. J. Lepr. Other Mycobact. Dis.
LA - eng
N2 - <p>A technique for immunoelectronmicroscopy has been used to investigate major histocompatibility class II expression in leprosy nerves. In normal nerves, endothelial cells and occasional endoneural cells (not Schwann cells) were constitutively class II positive. In both paucibacillary and multibacillary leprosy nerve biopsies, infiltrating leukocytes were positive but class II-positive Schwann cells were not seen. These observations indicate that Schwann cells may not be involved in presenting Mycobacterium leprae antigens to T cells in leprosy. This conflicts with evidence from in vitro studies, but may be explained by the fact that in vivo Schwann cells are surrounded by basement membranes and are closely associated with axons.</p>
PY - 1990
SP - 560
EP - 5
T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
TI - Major histocompatibility complex class II antigen expression in nerves in leprosy; an immunoelectronmicroscopical study.
UR - http://ila.ilsl.br/pdfs/v58n3a15.pdf
VL - 58
SN - 0148-916X
ER -