TY - JOUR KW - Hansen disease KW - tratamento KW - QcrB inhibitors KW - Bacteria KW - leprosy KW - telacebec KW - terminal oxidase KW - Tuberculosis and other mycobacteria AU - Lahiri R AU - Adams L AU - Thomas S AU - Pethe K AB -

The treatment of leprosy is long and complex, benefiting from the development of sterilizing, rapidly-acting drugs. Reductive evolution made Mycobacterium leprae exquisitely sensitive to Telacebec, a phase 2 drug candidate for tuberculosis The unprecedented potency of Telacebec against M. leprae warrants further validation in clinical trials.

BT - Emerging infectious diseases C1 -

https://www.ncbi.nlm.nih.gov/pubmed/35202539

DA - 03/2022 DO - 10.3201/eid2803.210394 IS - 3 J2 - Emerg Infect Dis LA - eng N2 -

The treatment of leprosy is long and complex, benefiting from the development of sterilizing, rapidly-acting drugs. Reductive evolution made Mycobacterium leprae exquisitely sensitive to Telacebec, a phase 2 drug candidate for tuberculosis The unprecedented potency of Telacebec against M. leprae warrants further validation in clinical trials.

PY - 2022 SP - 749 EP - 751 T2 - Emerging infectious diseases TI - Sensitivity of Mycobacterium leprae to Telacebec. UR - https://wwwnc.cdc.gov/eid/article/28/3/pdfs/21-0394.pdf VL - 28 SN - 1080-6059 ER -