Inflammatory disorders are associated with the activation of tryptophan (TRYP) catabolism the kynurenine pathway (KP). Several reports have demonstrated the role of KP in the immunopathophysiology of both leprosy and coronavirus disease 19 (COVID-19). The nervous system can be affected in infections caused by both and SARS-CoV-2, but the mechanisms involved in the peripheral neural damage induced by these infectious agents are not fully understood. In recent years KP has received greater attention due the importance of kynurenine metabolites in infectious diseases, immune dysfunction and nervous system disorders. In this review, we discuss how modulation of the KP may aid in controlling the damage to peripheral nerves and the effects of KP activation on neural damage during leprosy or COVID-19 individually and we speculate its role during co-infection.
BT - Frontiers in cellular and infection microbiology C1 -https://www.ncbi.nlm.nih.gov/pubmed/35281455
DA - 01/2022 DO - 10.3389/fcimb.2022.815738 J2 - Front Cell Infect Microbiol LA - eng N2 -Inflammatory disorders are associated with the activation of tryptophan (TRYP) catabolism the kynurenine pathway (KP). Several reports have demonstrated the role of KP in the immunopathophysiology of both leprosy and coronavirus disease 19 (COVID-19). The nervous system can be affected in infections caused by both and SARS-CoV-2, but the mechanisms involved in the peripheral neural damage induced by these infectious agents are not fully understood. In recent years KP has received greater attention due the importance of kynurenine metabolites in infectious diseases, immune dysfunction and nervous system disorders. In this review, we discuss how modulation of the KP may aid in controlling the damage to peripheral nerves and the effects of KP activation on neural damage during leprosy or COVID-19 individually and we speculate its role during co-infection.
PY - 2022 EP - 815738 T2 - Frontiers in cellular and infection microbiology TI - Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19. UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907883/pdf/fcimb-12-815738.pdf VL - 12 SN - 2235-2988 ER -