TY - JOUR
KW - General Energy
AU - Muthusamy S
AU - Vilvanathan SA
AU - Dhandapany SP
AU - Bhagat VM
AU - Chadha VK
AU - Sivashanmugam E
AU - Kamalanathan A
AU - Lakshmanan S
AU - Mani M
AB - <p>Background</p>

<p>Leprosy is one of the neglected tropical diseases (NTD) experiencing relative stagnancy in the global number of new cases.</p>

<p>Objective</p>

<p>This study aims to find the proportion of antimicrobial resistance in the clinical specimens of leprosy patients attending a tertiary care leprosy Institute in South India.</p>

<p>Materials and methods</p>

<p>Skin biopsy specimens (31&nbsp;Nos) were tested by Polymerase chain reaction (PCR) for identification of&nbsp;M.&nbsp;leprae, and PCR followed by DNA sequencing for antimicrobial resistance (AMR) detection.</p>

<p>Results</p>

<p>All 31 specimens tested for&nbsp;M.&nbsp;leprae&nbsp;identification were positive. Resistance to dapsone was 6.5%, while rifampicin and ofloxacin showed 100% sensitivity.</p>

<p>Conclusion</p>

<p>This study warrants the need for a vigilant surveillance mechanism to monitor the trend of antimicrobial resistance in leprosy.&nbsp;</p>

BT - Leprosy Review
DO - 10.47276/lr.93.4.370
IS - 4
LA - Eng
N2 - <p>Background</p>

<p>Leprosy is one of the neglected tropical diseases (NTD) experiencing relative stagnancy in the global number of new cases.</p>

<p>Objective</p>

<p>This study aims to find the proportion of antimicrobial resistance in the clinical specimens of leprosy patients attending a tertiary care leprosy Institute in South India.</p>

<p>Materials and methods</p>

<p>Skin biopsy specimens (31&nbsp;Nos) were tested by Polymerase chain reaction (PCR) for identification of&nbsp;M.&nbsp;leprae, and PCR followed by DNA sequencing for antimicrobial resistance (AMR) detection.</p>

<p>Results</p>

<p>All 31 specimens tested for&nbsp;M.&nbsp;leprae&nbsp;identification were positive. Resistance to dapsone was 6.5%, while rifampicin and ofloxacin showed 100% sensitivity.</p>

<p>Conclusion</p>

<p>This study warrants the need for a vigilant surveillance mechanism to monitor the trend of antimicrobial resistance in leprosy.&nbsp;</p>

PB - Lepra
PY - 2022
SP - 370
EP - 376
T2 - Leprosy Review
TI - Molecular detection of drug resistance in clinical specimens of leprosy patients from a tertiary care leprosy centre in South India
UR - https://leprosyreview.org/admin/public/api/lepra/website/getDownload/63945627afaac14a3c48a28b
VL - 93
SN - 2162-8807
ER -