TY - JOUR KW - General Energy AU - Muthusamy S AU - Vilvanathan SA AU - Dhandapany SP AU - Bhagat VM AU - Chadha VK AU - Sivashanmugam E AU - Kamalanathan A AU - Lakshmanan S AU - Mani M AB -
Background
Leprosy is one of the neglected tropical diseases (NTD) experiencing relative stagnancy in the global number of new cases.
Objective
This study aims to find the proportion of antimicrobial resistance in the clinical specimens of leprosy patients attending a tertiary care leprosy Institute in South India.
Materials and methods
Skin biopsy specimens (31 Nos) were tested by Polymerase chain reaction (PCR) for identification of M. leprae, and PCR followed by DNA sequencing for antimicrobial resistance (AMR) detection.
Results
All 31 specimens tested for M. leprae identification were positive. Resistance to dapsone was 6.5%, while rifampicin and ofloxacin showed 100% sensitivity.
Conclusion
This study warrants the need for a vigilant surveillance mechanism to monitor the trend of antimicrobial resistance in leprosy.
BT - Leprosy Review DO - 10.47276/lr.93.4.370 IS - 4 LA - Eng N2 -Background
Leprosy is one of the neglected tropical diseases (NTD) experiencing relative stagnancy in the global number of new cases.
Objective
This study aims to find the proportion of antimicrobial resistance in the clinical specimens of leprosy patients attending a tertiary care leprosy Institute in South India.
Materials and methods
Skin biopsy specimens (31 Nos) were tested by Polymerase chain reaction (PCR) for identification of M. leprae, and PCR followed by DNA sequencing for antimicrobial resistance (AMR) detection.
Results
All 31 specimens tested for M. leprae identification were positive. Resistance to dapsone was 6.5%, while rifampicin and ofloxacin showed 100% sensitivity.
Conclusion
This study warrants the need for a vigilant surveillance mechanism to monitor the trend of antimicrobial resistance in leprosy.
PB - Lepra PY - 2022 SP - 370 EP - 376 T2 - Leprosy Review TI - Molecular detection of drug resistance in clinical specimens of leprosy patients from a tertiary care leprosy centre in South India UR - https://leprosyreview.org/admin/public/api/lepra/website/getDownload/63945627afaac14a3c48a28b VL - 93 SN - 2162-8807 ER -