TY - JOUR KW - immune markers KW - inflammatory cytokine KW - leprosy KW - Leprosy complications KW - soluble TREM-1 AU - Bezerra-Santos M AU - Bomfim L AU - Santos C AU - Cunha M AU - de Moraes E AU - Cazzaniga R AU - Tenório M AU - Araujo J AU - Menezes-Silva L AU - Magalhães L AU - Barreto A AU - Reed S AU - Duthie M AU - Lipscomb M AU - de Almeida R AU - de Moura T AU - de Jesus A AB -

Leprosy reaction (LR) and physical disability (PD) are the most significant clinical complications of leprosy. Herein, we assessed the circulating serum-sTREM-1 and TNF-α levels and their genetic polymorphisms in leprosy. Serum-sTREM-1 and TNF-α levels were measured in leprosy patients (LP) before treatment ( = 51) and from their household contacts (HHCs; = 25). DNA samples were genotyped using TREM-1 rs2234246 and TNF-α rs1800629-SNP in 210 LPs and 168 endemic controls. The circulating sTREM-1 and TNF-α levels are higher in the multibacillary form. The ROC curve of the serum-sTREM-1 levels was able to differentiate LR from non-LR and PD from non-PD. Similarly, LPs with serum-sTREM-1 levels >210 pg/ml have 3-fold and 6-fold higher chances of presenting with LR and PD, respectively. Genotypes CC+CT of the TREM-1 were associated with leprosy. Taken together, our analyses indicated that sTREM-1 and TNF-α play an important role in the pathogenesis of leprosy and provide promising biomarkers to assist in the diagnosis of leprosy complications.

BT - Frontiers in medicine C1 -

https://www.ncbi.nlm.nih.gov/pubmed/37457576

DA - 01/2023 DO - 10.3389/fmed.2023.1177375 J2 - Front Med (Lausanne) LA - eng N2 -

Leprosy reaction (LR) and physical disability (PD) are the most significant clinical complications of leprosy. Herein, we assessed the circulating serum-sTREM-1 and TNF-α levels and their genetic polymorphisms in leprosy. Serum-sTREM-1 and TNF-α levels were measured in leprosy patients (LP) before treatment ( = 51) and from their household contacts (HHCs; = 25). DNA samples were genotyped using TREM-1 rs2234246 and TNF-α rs1800629-SNP in 210 LPs and 168 endemic controls. The circulating sTREM-1 and TNF-α levels are higher in the multibacillary form. The ROC curve of the serum-sTREM-1 levels was able to differentiate LR from non-LR and PD from non-PD. Similarly, LPs with serum-sTREM-1 levels >210 pg/ml have 3-fold and 6-fold higher chances of presenting with LR and PD, respectively. Genotypes CC+CT of the TREM-1 were associated with leprosy. Taken together, our analyses indicated that sTREM-1 and TNF-α play an important role in the pathogenesis of leprosy and provide promising biomarkers to assist in the diagnosis of leprosy complications.

PY - 2023 SP - 1 EP - 8 T2 - Frontiers in medicine TI - sTREM-1 and TNF-α levels are associated with the clinical outcome of leprosy patients. UR - https://www.frontiersin.org/articles/10.3389/fmed.2023.1177375/pdf VL - 10 SN - 2296-858X ER -