TY - JOUR KW - Australia KW - Buruli ulcer KW - Mycobacterium KW - Mycobacterium ulcerans KW - Bacteria KW - Case-Control Studies KW - Protective factors KW - Risk Factors KW - Tuberculosis and other mycobacteria KW - Vector-borne infections KW - Zoonoses AU - McNamara B AU - Blasdell K AU - Yerramilli A AU - Smith I AU - Clayton S AU - Dunn M AU - Tay E AU - Gibney K AU - Waidyatillake N AU - Hussain M AU - Muleme M AU - O'Brien D AU - Athan E AB -

To examine protective and risk factors for Buruli ulcer (BU), we conducted a case-control study of 245 adult BU cases and 481 postcode-matched controls across BU-endemic areas of Victoria, Australia. We calculated age- and sex-adjusted odds ratios for socio-environmental, host, and behavioral factors associated with BU by using conditional logistic regression. Odds of BU were >2-fold for persons with diabetes mellitus and persons working outdoors who had soil contact in BU-endemic areas (compared with indoor work) but were lower among persons who had bacillus Calmette-Guérin vaccinations. BU was associated with increasing numbers of possums and with ponds and bore water use at residences. Using insect repellent, covering arms and legs outdoors, and immediately washing wounds were protective; undertaking multiple protective behaviors was associated with the lowest odds of BU. Skin hygiene/protection behaviors and previous bacillus Calmette-Guérin vaccination might provide protection against BU in BU-endemic areas.

BT - Emerging infectious diseases C1 -

https://www.ncbi.nlm.nih.gov/pubmed/37735741

DA - 10/2023 DO - 10.3201/eid2910.230011 IS - 10 J2 - Emerg Infect Dis LA - eng N2 -

To examine protective and risk factors for Buruli ulcer (BU), we conducted a case-control study of 245 adult BU cases and 481 postcode-matched controls across BU-endemic areas of Victoria, Australia. We calculated age- and sex-adjusted odds ratios for socio-environmental, host, and behavioral factors associated with BU by using conditional logistic regression. Odds of BU were >2-fold for persons with diabetes mellitus and persons working outdoors who had soil contact in BU-endemic areas (compared with indoor work) but were lower among persons who had bacillus Calmette-Guérin vaccinations. BU was associated with increasing numbers of possums and with ponds and bore water use at residences. Using insect repellent, covering arms and legs outdoors, and immediately washing wounds were protective; undertaking multiple protective behaviors was associated with the lowest odds of BU. Skin hygiene/protection behaviors and previous bacillus Calmette-Guérin vaccination might provide protection against BU in BU-endemic areas.

PY - 2023 SP - 2032 EP - 2043 T2 - Emerging infectious diseases TI - Comprehensive Case-Control Study of Protective and Risk Factors for Buruli Ulcer, Southeastern Australia. UR - https://wwwnc.cdc.gov/eid/article/29/10/pdfs/23-0011.pdf VL - 29 SN - 1080-6059 ER -