BCG (bacille Calmette-Guérin) vaccines are at once among the least satisfactory and yet the most widely used of all vaccines today. Their variable efficacy against tuberculosis and leprosy is still not understood and points to a fundamental unsolved problem in vaccine immunology. The extensive use of BCG vaccines means that there are few BCG-free populations in the world that would be suitable for trials of future antimycobacterial vaccines. These facts have implications with regard to strategies for the development and testing of new vaccines against mycobacterial diseases.
BT - Reviews of infectious diseases C1 - http://www.ncbi.nlm.nih.gov/pubmed/2652252?dopt=Abstract DA - 1989 Mar-Apr DO - 10.1093/clinids/11.supplement_2.s353 J2 - Rev. Infect. Dis. LA - eng N2 -BCG (bacille Calmette-Guérin) vaccines are at once among the least satisfactory and yet the most widely used of all vaccines today. Their variable efficacy against tuberculosis and leprosy is still not understood and points to a fundamental unsolved problem in vaccine immunology. The extensive use of BCG vaccines means that there are few BCG-free populations in the world that would be suitable for trials of future antimycobacterial vaccines. These facts have implications with regard to strategies for the development and testing of new vaccines against mycobacterial diseases.
PY - 1989 SP - S353 EP - 9 T2 - Reviews of infectious diseases TI - The BCG story: lessons from the past and implications for the future. VL - 11 Suppl 2 SN - 0162-0886 ER -