While there are conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls, higher levels have been more evident in the tuberculoid clinical form of leprosy and type 1 reactions. This review aimed to highlight the role of Th17 cells and their cytokines in leprosy. Cytokines such as IL-1β and IL-23 induce Th17, while transforming growth factor beta and IL-10 inhibit Th17, indicating that the balance between Th17 and regulatory T cells is crucial for leprosy polarization. However, more comprehensive paired studies are required to better elucidate the role of Th17 cells in leprosy.
BT - Revista da Sociedade Brasileira de Medicina Tropical C1 -https://www.ncbi.nlm.nih.gov/pubmed/37909507
DA - 01/2023 DO - 10.1590/0037-8682-0265-2023 J2 - Rev Soc Bras Med Trop LA - eng N2 -While there are conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls, higher levels have been more evident in the tuberculoid clinical form of leprosy and type 1 reactions. This review aimed to highlight the role of Th17 cells and their cytokines in leprosy. Cytokines such as IL-1β and IL-23 induce Th17, while transforming growth factor beta and IL-10 inhibit Th17, indicating that the balance between Th17 and regulatory T cells is crucial for leprosy polarization. However, more comprehensive paired studies are required to better elucidate the role of Th17 cells in leprosy.
PY - 2023 SP - 1 EP - 5 T2 - Revista da Sociedade Brasileira de Medicina Tropical TI - Th17 Cells and Cytokines in Leprosy: Understanding the Immune Response and Polarization. UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615336/pdf/1678-9849-rsbmt-56-e0265-2023.pdf VL - 56 SN - 1678-9849 ER -